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Article

Itch regulation of innate and adaptive immune responses in mice and humans.

Journal of leukocyte biology - 1 Jul 2020

Field Natania S, Moser Emily K, Oliver Paula M

Abstract excerpt

The E3 ubiquitin ligase Itch has long been appreciated to be a critical suppressor of inflammation, first identified as a regulator of Th2 differentiation and lung inflammation. Recent studies have revealed novel roles for this protein in mouse and human disease, and it is now clear that Itch also limits the function of other lymphocytes, innate immune cells, and nonhematopoietic cells to regulate immunity. In...

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Identifiers

PMID: 32356405
DOI: 10.1002/JLB.3MIR0320-272R
PMCID: PMC7489470

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