Article
IL-17-driven intestinal fibrosis is inhibited by Itch-mediated ubiquitination of HIC-5.
Mucosal immunology - 1 Mar 2018
Paul J, Singh A K, Kathania M, Elviche T L, Zeng M, Basrur V, Theiss A L, Venuprasad K
Abstract excerpt
Intestinal fibrosis is a major complication in inflammatory bowel diseases, but the regulatory mechanism that inhibits fibrosis remains unclear. Here we demonstrate that Itch-/-myofibroblasts express increased amounts of profibrotic collagen type I and α-SMA in response to IL-17. Mechanistically, we demonstrate that Itch directly binds to HIC-5 and targets it for K63-linked ubiquitination to inhibit IL-17-driven...
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