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Article

Case report: Analysis of BRCA1 and BRCA2 gene mutations in a hereditary ovarian cancer family.

Journal of assisted reproduction and genetics - 1 Jun 2020

Liao Ying, Tu Chunhua, Song Xiaoxia, Cai Liping

Abstract excerpt

OBJECTIVE: Breast cancer susceptibility gene 1/2 (BRCA1/2) is the most important susceptibility gene associated with hereditary ovarian cancer (HOC). We aimed to screen BRAC1 and BRAC2 gene mutations in a member of a hereditary ovarian cancer family in China, and to analyze the structure and function of the mutant protein. METHODS: A typical HOC family was selected. Blood samples and pathological tissue samples...

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Identifiers

PMID: 32356124
DOI: 10.1007/s10815-020-01783-w
PMCID: PMC7311593

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