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Article

Genetic and clinical characteristics in Japanese hereditary breast and ovarian cancer: first report after establishment of HBOC registration system in Japan.

Journal of human genetics - 1 Apr 2018

Arai Masami, Yokoyama Shiro, Watanabe Chie, Yoshida Reiko, Kita Mizuho, Okawa Megumi, Sakurai Akihiro, Sekine Masayuki, Yotsumoto Junko, Nomura Hiroyuki, Akama Yoshinori, Inuzuka Mayuko, Nomizu Tadashi, Enomoto Takayuki, Nakamura Seigo

Abstract excerpt

The hereditary breast and ovarian cancer (HBOC) registration system of Japan was established by the Japanese HBOC Consortium. The first trial was registered in 2015 in four institutions to which some registration committee members belonged. We analyzed the information of 830 Japanese pedigrees, who underwent BRCA1/2 genetic testing, including mutation carriers with BRCA1 (N = 127) and BRCA2 (N = 115), and their...

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Identifiers

PMID: 29176636
DOI: 10.1038/s10038-017-0355-1
PMCID: PMC8716335

Genes

BRCA1
BRCA2

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Source receipt: pubmed, retrieved 7 Sept 2026.

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