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Article

Genomic copy number variation correlates with survival outcomes in WHO grade IV glioma.

Scientific reports - 30 Apr 2020

Buchwald Zachary S, Tian Sibo, Rossi Michael, Smith Geoffrey H, Switchenko Jeffrey, Hauenstein Jennifer E, Moreno Carlos S, Press Robert H, Prabhu Roshan S, Zhong Jim, Saxe Debra F, Neill Stewart G, Olson Jeffrey J, Crocker Ian R, Curran Walter J, Shu Hui-Kuo G

Abstract excerpt

Allele-specific copy number analysis of tumors (ASCAT) assesses copy number variations (CNV) while accounting for aberrant cell fraction and tumor ploidy. We evaluated if ASCAT-assessed CNV are associated with survival outcomes in 56 patients with WHO grade IV gliomas. Tumor data analyzed by Affymetrix OncoScan FFPE Assay yielded the log ratio (R) and B-allele frequency (BAF). Input into ASCAT quantified CNV...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32355162
DOI: 10.1038/s41598-020-63789-9
PMCID: PMC7192941

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