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Article

Sensor Histidine Kinase NarQ Activates via Helical Rotation, Diagonal Scissoring, and Eventually Piston-Like Shifts.

International journal of molecular sciences - 28 Apr 2020

Gushchin Ivan, Orekhov Philipp, Melnikov Igor, Polovinkin Vitaly, Yuzhakova Anastasia, Gordeliy Valentin

Abstract excerpt

Membrane-embedded sensor histidine kinases (HKs) and chemoreceptors are used ubiquitously by bacteria and archaea to percept the environment, and are often crucial for their survival and pathogenicity. The proteins can transmit the signal from the sensor domain to the catalytic kinase domain reliably over the span of several hundreds of angstroms, and regulate the activity of the cognate response regulator...

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PMID: 32354084
DOI: 10.3390/ijms21093110
PMCID: PMC7247690

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