Article
Longevity Relatives Count score identifies heritable longevity carriers and suggests case improvement in genetic studies.
Aging cell - 1 Jun 2020
van den Berg Niels, Rodríguez-Girondo Mar, Mandemakers Kees, Janssens Angelique A P O, Beekman Marian, Slagboom P Eline
Abstract excerpt
Loci associated with longevity are likely to harbor genes coding for key players of molecular pathways involved in a lifelong decreased mortality and decreased/compressed morbidity. However, identifying such loci is challenging. One of the most plausible reasons is the uncertainty in defining long-lived cases with the heritable longevity trait among long-living phenocopies. To avoid phenocopies, family selection...
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