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Genome analysis of peeling archival cytology samples detects driver mutations in lung cancer.

Cancer medicine - 1 Jul 2020

Kunimasa Kei, Hirotsu Yosuke, Amemiya Kenji, Nagakubo Yuki, Goto Taichiro, Miyashita Yoshihiro, Kakizaki Yumiko, Tsutsui Toshiharu, Otake Sotaro, Kobayashi Hiroaki, Higuchi Rumi, Inomata Kie, Kumagai Takashi, Mochizuki Hitoshi, Nakamura Harumi, Nakatsuka Shin-Ichi, Nishino Kazumi, Imamura Fumio, Kumagai Toru, Oyama Toshio, Omata Masao

Abstract excerpt

INTRODUCTIONS: When tumor tissue samples are unavailable to search for actionable driver mutations, archival cytology samples can be useful. We investigate whether archival cytology samples can yield reliable genomic information compared to corresponding formalin-fixed paraffin-embedded (FFPE) tumor samples. PATIENTS AND METHODS: Pretreatment class V archival cytology samples with adequate tumor cells were...

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PMID: 32351019
DOI: 10.1002/cam4.3089
PMCID: PMC7333826

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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