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Cytology smears as excellent starting material for next-generation sequencing-based molecular testing of patients with adenocarcinoma of the lung.

Cancer cytopathology - 1 Jan 2017

Velizheva Nadezda P, Rechsteiner Markus P, Wong Christine E, Zhong Qing, Rössle Matthias, Bode Beata, Moch Holger, Soltermann Alex, Wild Peter J, Tischler Verena

Abstract excerpt

BACKGROUND: Molecular testing of lung adenocarcinomas (ADCs) is crucial for therapy stratification of patients. Because of the often limited diagnostic material, the authors aimed to explore the suitability of cytology smears for next-generation sequencing (NGS) and compared the results with concurrent histological specimens or cell blocks. METHODS: A total of 16 formalin-fixed paraffin-embedded (FFPE) ADCs with...

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PMID: 27636102
DOI: 10.1002/cncy.21771

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