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Mathematical modeling of human oocyte aneuploidy

29 Apr 2020

Abstract excerpt

Aneuploidy is the leading contributor to pregnancy loss, congenital anomalies, and in vitro fertilization (IVF) failure in humans. Although most aneuploid conceptions are thought to originate from meiotic division errors in the female germline, quantitative studies that link the observed phenotypes to underlying error mechanisms are lacking. In this study, we developed a mathematical modeling framework to...

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PMID: 32350135
DOI: 10.1073/pnas.1912853117

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