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Concentrations of oocyte secreted GDF9 and BMP15 decrease with MII transition during human IVM

19 Aug 2022

Abstract excerpt

BACKGROUND: The suggested effects of the oocyte secreted GDF9 and BMP15 growth factors on oocyte maturation are currently based on recombinant proteins, and little is known about native GDF9 and BMP15 in humans. METHODS: Human immature cumulus-oocyte complexes (COCs) obtained in connection with ovarian tissue cryopreservation (OTC) underwent in vitro maturation (IVM). Oocyte-produced GDF9 and BMP15 were detected...

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PMID: 35986324
DOI: 10.1186/s12958-022-01000-6

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