Molecular Aspects and Clinical Relevance of GDF9 and BMP15 in Ovarian Function.

doi:10.1016/bs.vh.2017.12.003

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Article

Molecular Aspects and Clinical Relevance of GDF9 and BMP15 in Ovarian Function.

Vitamins and hormones - 1 Jan 2018

Belli Martina, Shimasaki Shunichi

Abstract excerpt

Growth and differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) are oocyte-secreted factors with a leading role in the control of ovarian function in female reproduction, modulating both the cell fate of the somatic granulosa cells and the quality and developmental competence of the egg. This short review aims to consolidate the molecular aspects of GDF9 and BMP15 and their integral actions...

Topics

Animals
Bone Morphogenetic Protein 15
Female
Gene Expression Regulation, Developmental
Genetic Predisposition to Disease
Granulosa Cells
Growth Differentiation Factor 9
Humans
Menstrual Cycle
Mutation
Oocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oogenesis

Ovary

Polycystic Ovary Syndrome

Pregnancy

Pregnancy, Twin

Primary Ovarian Insufficiency

Protein Conformation

Source

Open in PubMed Open full text

Identifiers

PMID: 29544636
DOI: 10.1016/bs.vh.2017.12.003
PMCID: PMC6309678

Genes

BMP15
GDF9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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