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Article

BMP15 Mutations Associated With Primary Ovarian Insufficiency Reduce Expression, Activity, or Synergy With GDF9.

The Journal of clinical endocrinology and metabolism - 1 Mar 2017

Patiño Liliana C, Walton Kelly L, Mueller Thomas D, Johnson Katharine E, Stocker William, Richani Dulama, Agapiou David, Gilchrist Robert B, Laissue Paul, Harrison Craig A

Abstract excerpt

CONTEXT: Bone morphogenetic protein (BMP)15 is an oocyte-specific growth factor, which, together with growth differentiation factor (GDF) 9, regulates folliculogenesis and ovulation rate. Multiple mutations in BMP15 have been identified in women with primary ovarian insufficiency (POI), supporting a pathogenic role; however, the underlying biological mechanism of many of these mutants remains unresolved....

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Share to Bone Morphogenetic Protein 15
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28359091
DOI: 10.1210/jc.2016-3503

Genes

BMP15
GDF9

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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