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Article

Phosphorylated TDP-43 in Alzheimer's disease and dementia with Lewy bodies.

Acta neuropathologica - 1 Feb 2009

Arai Tetsuaki, Mackenzie Ian R A, Hasegawa Masato, Nonoka Takashi, Niizato Kazhuhiro, Tsuchiya Kuniaki, Iritani Shuji, Onaya Mitsumoto, Akiyama Haruhiko

Abstract excerpt

Phosphorylated and proteolytically cleaved TDP-43 is a major component of the ubiquitin-positive inclusions in the most common pathological subtype of frontotemporal lobar degeneration (FTLD-U). Intracellular accumulation of TDP-43 is observed in a subpopulation of patients with other dementia disorders, including Alzheimer's disease (AD) and dementia with Lewy bodies (DLB). However, the pathological significance...

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Identifiers

PMID: 19139911
DOI: 10.1007/s00401-008-0480-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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