Article
Knockout of E2F1 enhances the polarization of M2 phenotype macrophages to accelerate the wound healing process.
The Kaohsiung journal of medical sciences - 1 Sept 2020
Xiao Hui, Wu Yi-Ping, Yang Chang-Chun, Yi Zhen, Zeng Ning, Xu Yi, Zeng Hong, Deng Pei, Zhang Qi, Wu Min
Abstract excerpt
Wound healing is a complex process, which is classically divided into inflammation, proliferation, and remodeling phases. Macrophages play a key role in wound healing, however, whether E2F1 mediates the M1/M2 polarization during the wound healing process is not known. Skin wounds were surgically induced in E2F1-/- mice and their WT littermates. At day 2 and day 7 post-surgery, the wounded skin tissues including 2...
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