Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of mTORC2 as a Necessary Component of HRG/ErbB2-Dependent Cellular Transformation

10 Mar 2014

Abstract excerpt

UNLABELLED: Overexpression of the receptor tyrosine kinase HER2/ErbB2 (ERBB2) has been linked to a poor prognosis for patients with breast cancer; thus, its activity is a central target for cancer therapy. Likewise, overexpression of heregulin (HRG/NRG1), a growth factor responsible for ErbB2 activation, has also been shown to be a driver of breast cancer progression. Although ErbB2 inhibitors offer a major...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Advanced Breast Cancer Therapies
Share to HER2/EGFR in Cancer Research
Share to PI3K/AKT/mTOR signaling in cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24615340
DOI: 10.1158/1541-7786.mcr-13-0555

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of mTORC2 as a Necessary Component of HRG/ErbB2-Dependent Cellular TransformationPMID 24615340Read ↗

Rheb1-Independent Activation of mTORC1 in Mammary Tumors Occurs through Activating Mutations in mTOR.Semantic proximity Read ↗

Strategic Developments & Future Perspective on Gene Therapy for Breast Cancer: Role of mTOR and Brk/ PTK6 as Molecular TargetsSemantic proximity Read ↗

Targeting the PI3K/AKT/mTOR Pathway in Hormone-Positive Breast Cancer.Semantic proximity Read ↗

A global microRNA screen identifies regulators of the ErbB receptor signaling networkSemantic proximity Read ↗

DNA damage-induced S and G2/M cell cycle arrest requires mTORC2-dependent regulation of Chk1Semantic proximity Read ↗

The phosphoinositide-3-kinase-Akt-mTOR pathway as a therapeutic target in breast cancer.Semantic proximity Read ↗

Combined Inhibition of mTOR and CDK4/6 Is Required for Optimal Blockade of E2F Function and Long-term Growth Inhibition in Estrogen Receptor–positive Breast CancerSemantic proximity Read ↗

Targeting the mTORC2 signaling complex in B cell malignanciesSemantic proximity Read ↗

RUNX1/EGFR pathway contributes to STAT3 activation and tumor growth caused by hyperactivated mTORC1Semantic proximity Read ↗

RICTOR involvement in the PI3K/AKT pathway regulation in melanocytes and melanoma.Semantic proximity Read ↗

Prognostic and therapeutic implications of mTORC1 and Rictor expression in human breast cancerSemantic proximity Read ↗

RICTOR Amplification Defines a Novel Subset of Patients with Lung Cancer Who May Benefit from Treatment with mTORC1/2 Inhibitors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.