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Article

The mitochondrial metabolic checkpoint in stem cell aging and rejuvenation.

Mechanisms of ageing and development - 1 Jun 2020

Mu Wei-Chieh, Ohkubo Rika, Widjaja Andrew, Chen Danica

Abstract excerpt

Stem cell aging contributes to aging-associated tissue degeneration and dysfunction. Recent studies reveal a mitochondrial metabolic checkpoint that regulates stem cell quiescence and maintenance, and dysregulation of the checkpoint leads to functional deterioration of aged stem cells. Here, we present the evidence supporting the mitochondrial metabolic checkpoint regulating stem cell aging and demonstrating the...

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Identifiers

PMID: 32343979
DOI: 10.1016/j.mad.2020.111254
PMCID: PMC7375904

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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