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Article

Structural Variant in Mitochondrial-Associated Gene (MRPL3) Induces Adult-Onset Neurodegeneration with Memory Impairment in the Mouse.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 3 Jun 2020

Cahill Lindsay S, Cameron Jessie M, Winterburn Julie, Macos Patrick, Hoggarth Johnathan, Dzamba Misko, Brudno Michael, Nutter Lauryl M J, Sproule Thomas J, Burgess Robert W, Henkelman R Mark, Sled John G

Abstract excerpt

An impediment to the development of effective therapies for neurodegenerative disease is that available animal models do not reproduce important clinical features such as adult-onset and stereotypical patterns of progression. Using in vivo magnetic resonance imaging and behavioral testing to study male and female decrepit mice, we found a stereotypical neuroanatomical pattern of progression of the lesion along...

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Identifiers

PMID: 32341096
DOI: 10.1523/JNEUROSCI.0013-20.2020
PMCID: PMC7275855

Genes

MRPL3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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