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Notch signaling regulates cardiomyocyte proliferation during zebrafish heart regeneration

13 Jan 2014

Abstract excerpt

The human heart's failure to replace ischemia-damaged myocardium with regenerated muscle contributes significantly to the worldwide morbidity and mortality associated with coronary artery disease. Remarkably, certain vertebrate species, including the zebrafish, achieve complete regeneration of amputated or injured myocardium through the proliferation of spared cardiomyocytes. Nonetheless, the genetic and cellular...

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PMID: 24474765
DOI: 10.1073/pnas.1311705111

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