Modeling biological and genetic diversity in upper tract urothelial carcinoma with patient derived xenografts.

doi:10.1038/s41467-020-15885-7

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Article

Modeling biological and genetic diversity in upper tract urothelial carcinoma with patient derived xenografts.

Nature communications - 24 Apr 2020

Kim Kwanghee, Hu Wenhuo, Audenet François, Almassi Nima, Hanrahan Aphrothiti J, Murray Katie, Bagrodia Aditya, Wong Nathan, Clinton Timothy N, Dason Shawn, Mohan Vishnu, Jebiwott Sylvia, Nagar Karan, Gao Jianjiong, Penson Alex, Hughes Chris, Gordon Benjamin, Chen Ziyu, Dong Yiyu, Watson Philip A, Alvim Ricardo, Elzein Arijh, Gao Sizhi P, Cocco Emiliano, Santin Alessandro D, Ostrovnaya Irina, Hsieh James J, Sagi Irit, Pietzak Eugene J, Hakimi A Ari, Rosenberg Jonathan E, Iyer Gopa, Vargas Herbert A, Scaltriti Maurizio, Al-Ahmadie Hikmat, Solit David B, Coleman Jonathan A

Abstract excerpt

Treatment paradigms for patients with upper tract urothelial carcinoma (UTUC) are typically extrapolated from studies of bladder cancer despite their distinct clinical and molecular characteristics. The advancement of UTUC research is hampered by the lack of disease-specific models. Here, we report the establishment of patient derived xenograft (PDX) and cell line models that reflect the genomic and biological...

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PMID: 32332851
DOI: 10.1038/s41467-020-15885-7
PMCID: PMC7181640

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