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Article

Cytogenetic effects of antidiabetic drug metformin

8 Nov 2020

Abstract excerpt

Metformin (MET) is the first-choice antidiabetic drug for type 2 diabetes mellitus treatment. In this study, the genotoxic potential of MET was evaluated by using chromosome aberrations (CAs), sister chromatid exchanges (SCEs), and micronucleus (MN) assays in human peripheral lymphocytes as well as comet assay in isolated lymphocytes. Human lymphocytes were treated with different concentrations of MET (12.5, 25,...

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PMID: 33161761
DOI: 10.1080/01480545.2020.1844226

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