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Article

Intratumor δ-catenin heterogeneity driven by genomic rearrangement dictates growth factor dependent prostate cancer progression.

Oncogene - 1 May 2020

Li Mingchuan, Nopparat Jongdee, Aguilar Byron J, Chen Yan-Hua, Zhang Jiao, Du Jie, Ai Xin, Luo Yong, Jiang Yongguang, Boykin Christi, Lu Qun

Abstract excerpt

Only a small number of genes are bona fide oncogenes and tumor suppressors such as Ras, Myc, β-catenin, p53, and APC. However, targeting these cancer drivers frequently fail to demonstrate sustained cancer remission. Tumor heterogeneity and evolution contribute to cancer resistance and pose challenges for cancer therapy due to differential genomic rearrangement and expression driving distinct tumor responses to...

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Identifiers

PMID: 32313227
DOI: 10.1038/s41388-020-1281-9
PMCID: PMC10493073

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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