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Article

Serum phosphorylated neurofilament heavy-chain levels reflect phenotypic heterogeneity and are an independent predictor of survival in motor neuron disease.

Journal of neurology - 1 Aug 2020

Falzone Yuri Matteo, Domi Teuta, Agosta Federica, Pozzi Laura, Schito Paride, Fazio Raffaella, Del Carro Ubaldo, Barbieri Alessandra, Comola Mauro, Leocani Letizia, Comi Giancarlo, Carrera Paola, Filippi Massimo, Quattrini Angelo, Riva Nilo

Abstract excerpt

To investigate the prognostic role and the major determinants of serum phosphorylated neurofilament heavy -chain (pNfH) concentration across a large cohort of motor neuron disease (MND) phenotypes. Enzyme-linked immunosorbent assay (ELISA) was used to measure serum pNfH concentration in 219 MND patients consecutively enrolled in our tertiary MND clinic. A multifactorial analysis was carried out to investigate the...

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Identifiers

PMID: 32306171
DOI: 10.1007/s00415-020-09838-9
PMCID: PMC7166001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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