Plasma Neurofilaments: Potential Biomarkers of SPG11 ‐Related Hereditary Spastic Paraplegia

Abstract excerpt

Hereditary spastic paraplegias (HSPs) are characterized by progressive lower-limb spasticity due to a length-dependent axonopathy of the corticospinal tract.1 The complexity regarding genotypes, presence of additional symptoms, and rate of progression has complicated the definition of biomarkers as outcome parameters. Neurofilament light chain (NfL) and neurofilament heavy chain (NfH) have emerged as potential...