Article
Defective arginine metabolism impairs mitochondrial homeostasis in Caenorhabditiselegans.
Journal of genetics and genomics = Yi chuan xue bao - 20 Mar 2020
Tang Ruofeng, Wang Xin, Zhou Junxiang, Zhang Fengxia, Zhao Shan, Gan Qiwen, Zhao Liyuan, Wang Fengyang, Zhang Qian, Zhang Jie, Wang Guodong, Yang Chonglin
Abstract excerpt
Arginine catabolism involves enzyme-dependent reactions in both mitochondria and the cytosol, defects in which may lead to hyperargininemia, a devastating developmental disorder. It is largely unknown if defective arginine catabolism has any effects on mitochondria. Here we report that normal arginine catabolism is essential for mitochondrial homeostasis in Caenorhabditiselegans. Mutations of the arginase gene...
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