Article
Metabolic characterization of colorectal cancer cells harbouring different KRAS mutations in codon 12, 13, 61 and 146 using human SW48 isogenic cell lines.
Metabolomics : Official journal of the Metabolomic Society - 16 Apr 2020
Varshavi Dorna, Varshavi Dorsa, McCarthy Nicola, Veselkov Kirill, Keun Hector C, Everett Jeremy R
Abstract excerpt
INTRODUCTION: Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) mutations occur in approximately one-third of colorectal (CRC) tumours and have been associated with poor prognosis and resistance to some therapeutics. In addition to the well-documented pro-tumorigenic role of mutant Ras alleles, there is some evidence suggesting that not all KRAS mutations are equal and the position and type of amino acid...
Topics
- Colorectal Neoplasms
- Humans
- Metabolomics
- Mutation
- Proto-Oncogene Proteins p21(ras)
- Tumor Cells, Cultured