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Whole-exome Sequencing of Nigerian Prostate Tumors from the Prostate Cancer Transatlantic Consortium (CaPTC) Reveals DNA Repair Genes Associated with African Ancestry.

Cancer research communications - 1 Sept 2022

White Jason A, Kaninjing Ernest T, Adeniji Kayode A, Jibrin Paul, Obafunwa John O, Ogo Chidiebere N, Mohammed Faruk, Popoola Ademola, Fatiregun Omolara A, Oluwole Olabode P, Karanam Balasubramanyam, Elhussin Isra, Ambs Stefan, Tang Wei, Davis Melissa, Polak Paz, Campbell Moray J, Brignole Kathryn R, Rotimi Solomon O, Dean-Colomb Windy, Odedina Folake T, Martin Damali N, Yates Clayton

Abstract excerpt

In this study, we used whole-exome sequencing of a cohort of 45 advanced-stage, treatment-naïve Nigerian (NG) primary prostate cancer tumors and 11 unmatched nontumor tissues to compare genomic mutations with African American (AA) and European American (EA) The Cancer Genome Atlas (TCGA) prostate cancer. NG samples were collected from six sites in central and southwest Nigeria. After whole-exome sequencing,...

Topics

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DNA Repair
Exome Sequencing
BARD1 gene
MLH1 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mismatch Repair Endonuclease PMS2

Prostatic Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 36922933
DOI: 10.1158/2767-9764.CRC-22-0136
PMCID: PMC10010347

Genes

BRCA1
BRCA2
PMS2
APC
BARD1
ATM
DNAJC6
EGFR
MAD1L1
MLH1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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