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Distinct Genomic Alterations in Prostate Tumors Derived from African American Men.

Molecular cancer research : MCR - 1 Dec 2020

Liu Wennuan, Zheng S Lilly, Na Rong, Wei Lin, Sun Jishan, Gallagher Johnie, Wei Jun, Resurreccion W Kyle, Ernst Sarah, Sfanos Karen S, Isaacs William B, Xu Jianfeng

Abstract excerpt

We aim to understand, from acquired genetic alterations in tumors, why African American (AA) men are more likely to develop aggressive prostate cancer. By analyzing somatic mutations in 39 genes using deeper next-generation sequencing with an average depth of 2,522 reads for tumor DNA and genome-wide DNA copy-number alterations (CNA) in prostate cancer in a total of 171 AA/black men and comparing with those in...

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PMID: 33115829
DOI: 10.1158/1541-7786.MCR-20-0648

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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