Article
Whole-genome genotyping and resequencing reveal the association of a deletion in the complex interferon alpha gene cluster with hypothyroidism in dogs.
BMC genomics - 16 Apr 2020
Bianchi Matteo, Rafati Nima, Karlsson Åsa, Murén Eva, Rubin Carl-Johan, Sundberg Katarina, Andersson Göran, Kämpe Olle, Hedhammar Åke, Lindblad-Toh Kerstin, Rosengren Pielberg Gerli
Abstract excerpt
BACKGROUND: Hypothyroidism is a common complex endocrinopathy that typically has an autoimmune etiology, and it affects both humans and dogs. Genetic and environmental factors are both known to play important roles in the disease development. In this study, we sought to identify the genetic risk factors potentially involved in the susceptibility to the disease in the high-risk Giant Schnauzer dog breed. RESULTS:...
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