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Article

A variant in RESF1 is associated with Addison's disease and multiple autoimmune syndrome in young Nova Scotia Duck Tolling Retrievers.

Scientific reports - 12 Mar 2026

Brown Emily, Varney Scarlett, Young Amy, Wolf Zena, Foreman Oded, Wade Claire M, Hughes Angela, Oberbauer Anita, Safra Noa, Lindblad-Toh Kerstin, Burton Shelley, Bannasch Danika

Abstract excerpt

Addison's disease (AD) results in glucocorticoid and mineralocorticoid deficiencies and is often immune-mediated. While AD is uncommon in dogs, Nova Scotia Duck Tolling Retrievers (NSDTRs) exhibit increased incidence, suggesting genetic predisposition. Detailed clinical evaluation of 24 juvenile-onset cases revealed that while all dogs presented with adrenal insufficiency, at least 10 dogs (41.7%) had concurrent...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41813921
DOI: 10.1038/s41598-026-42994-y
PMCID: PMC13103380

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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