Article
A novel canine reference genome resolves genomic architecture and uncovers transcript complexity.
Communications biology - 10 Feb 2021
Wang Chao, Wallerman Ola, Arendt Maja-Louise, Sundström Elisabeth, Karlsson Åsa, Nordin Jessika, Mäkeläinen Suvi, Pielberg Gerli Rosengren, Hanson Jeanette, Ohlsson Åsa, Saellström Sara, Rönnberg Henrik, Ljungvall Ingrid, Häggström Jens, Bergström Tomas F, Hedhammar Åke, Meadows Jennifer R S, Lindblad-Toh Kerstin
Abstract excerpt
We present GSD_1.0, a high-quality domestic dog reference genome with chromosome length scaffolds and contiguity increased 55-fold over CanFam3.1. Annotation with generated and existing long and short read RNA-seq, miRNA-seq and ATAC-seq, revealed that 32.1% of lifted over CanFam3.1 gaps harboured previously hidden functional elements, including promoters, genes and miRNAs in GSD_1.0. A catalogue of canine "dark"...
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