Article
A Multi-Breed Genome-Wide Association Analysis for Canine Hypothyroidism Identifies a Shared Major Risk Locus on CFA12.
PloS one - 1 Jan 2015
Bianchi Matteo, Dahlgren Stina, Massey Jonathan, Dietschi Elisabeth, Kierczak Marcin, Lund-Ziener Martine, Sundberg Katarina, Thoresen Stein Istre, Kämpe Olle, Andersson Göran, Ollier William E R, Hedhammar Åke, Leeb Tosso, Lindblad-Toh Kerstin, Kennedy Lorna J, Lingaas Frode, Rosengren Pielberg Gerli
Abstract excerpt
Hypothyroidism is a complex clinical condition found in both humans and dogs, thought to be caused by a combination of genetic and environmental factors. In this study we present a multi-breed analysis of predisposing genetic risk factors for hypothyroidism in dogs using three high-risk breeds--the Gordon Setter, Hovawart and the Rhodesian Ridgeback. Using a genome-wide association approach and meta-analysis, we...
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