Article
Characterization of muscle filamin isoforms suggests a possible role of ?-filamin/ABP-L in sarcomeric Z-disc formation
1 Feb 2000
Abstract excerpt
Filamin, also called actin binding protein-280, is a dimeric protein that cross-links actin filaments in the cortical cytoplasm. In addition to this ubiquitously expressed isoform (FLN1), a second isoform (ABP-L/gamma-filamin) was recently identified that is highly expressed in mammalian striated muscles. A monoclonal antibody was developed, that enabled us to identify filamin as a Z-disc protein in mammalian...
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