Functional Interactomes of Genes Showing Association with Type-2 Diabetes and Its Intermediate Phenotypic Traits Point towards Adipo-Centric Mechanisms in Its Pathophysiology.

Abstract excerpt

The pathogenic mechanisms causing type 2 diabetes (T2D) are still poorly understood; a greater awareness of its causation can lead to the development of newer and better antidiabetic drugs. In this study, we used a network-based approach to assess the cellular processes associated with protein-protein interaction subnetworks of glycemic traits-HOMA-β and HOMA-IR. Their subnetworks were further analyzed in terms...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Adipose Tissue
• Share to Diabetes Mellitus, Type 2