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Article

ML264 inhibits osteosarcoma growth and metastasis via inhibition of JAK2/STAT3 and WNT/β-catenin signalling pathways.

Journal of cellular and molecular medicine - 1 May 2020

Huang Hai, Han Ying, Chen Zhijun, Pan Xin, Yuan Putao, Zhao Xiangde, Zhu Hongfang, Wang Jiying, Sun Xuewu, Shi Peihua

Abstract excerpt

Osteosarcoma, the most common bone malignancy, has a high morbidity rate and poor prognosis. Krüppel-like factor 5 (KLF5) is a key transcriptional regulator of cellular proliferation whose overexpression is observed in osteosarcoma cell lines (U2OS, 143B, MG63 and SAOS2). ML264, a small-molecule inhibitor of KLF5, exerts antiproliferative effects in colorectal cancer; however, its function in osteosarcoma remains...

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Identifiers

PMID: 32285603
DOI: 10.1111/jcmm.15226
PMCID: PMC7214147

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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