Article
Analysis of the BRAF V600E mutation in primary cutaneous melanoma.
Genetics and molecular research : GMR - 22 Jan 2014
Inumaru J S S, Gordo K I F, Fraga Junior A C, Silva A M T C, Leal C B Q S, Ayres F M, Wastowski I J, Borges N F, Saddi V A
Abstract excerpt
BRAF V600E is the most common mutation in cutaneous melanomas, and has been described in 30-72% of such cases. This mutation results in the substitution of valine for glutamic acid at position 600 of the BRAF protein, which consequently becomes constitutively activated. The present study investigated the BRAF V600E mutation frequency and its clinical implications in a group of 77 primary cutaneous melanoma...
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