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Article

Somatic mutations in 33 benign and malignant hot thyroid nodules in children and adolescents.

Molecular and cellular endocrinology - 5 Aug 2014

Eszlinger Markus, Niedziela Marek, Typlt Eva, Jaeschke Holger, Huth Sandra, Schaarschmidt Jörg, Aigner Thomas, Trejster Ewa, Krohn Knut, Bösenberg Eileen, Paschke Ralf

Abstract excerpt

Hot thyroid nodules (HTNs) in children are rare. Their reported malignancy rate is higher than in adults. However molecular data are rare. We present clinical and molecular data for 33 consecutive (29 benign and 4 malignant) HTNs. 17/29 Benign HTNs (59%) harbored somatic TSHR mutations. The most commonly observed mutation was M453T (in 8/29 samples). T632I and D633Y mutations were each detected twice. All other...

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Source

Identifiers

PMID: 24915144
DOI: 10.1016/j.mce.2014.05.023

Genes

TSHR
PAX8
PPARG
BRAF
NRAS
RET

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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