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Article

Keratin Dynamics and Spatial Distribution in Wild-Type and K14 R125P Mutant Cells-A Computational Model.

International journal of molecular sciences - 9 Apr 2020

Gouveia Marcos, Zemljič-Jokhadar Špela, Vidak Marko, Stojkovič Biljana, Derganc Jure, Travasso Rui, Liovic Mirjana

Abstract excerpt

Keratins are one of the most abundant proteins in epithelial cells. They form a cytoskeletal filament network whose structural organization seriously conditions its function. Dynamic keratin particles and aggregates are often observed at the periphery of mutant keratinocytes related to the hereditary skin disorder epidermolysis bullosa simplex, which is due to mutations in keratins 5 and 14. To account for their...

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Identifiers

PMID: 32283594
DOI: 10.3390/ijms21072596
PMCID: PMC7177522

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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