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Article

A Drosophila Model of Epidermolysis Bullosa Simplex.

The Journal of investigative dermatology - 1 Aug 2015

Bohnekamp Jens, Cryderman Diane E, Paululat Achim, Baccam Gabriel C, Wallrath Lori L, Magin Thomas M

Abstract excerpt

The blistering skin disorder epidermolysis bullosa simplex (EBS) results from dominant mutations in keratin 5 (K5) or keratin 14 (K14) genes, encoding the intermediate filament (IF) network of basal epidermal keratinocytes. The mechanisms governing keratin network formation and collapse due to EBS mutations remain incompletely understood. Drosophila lacks cytoplasmic IFs, providing a 'null' environment to examine...

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Identifiers

PMID: 25830653
DOI: 10.1038/jid.2015.129
PMCID: PMC4519992

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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