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Article

Threonine 150 Phosphorylation of Keratin 5 Is Linked to Epidermolysis Bullosa Simplex and Regulates Filament Assembly and Cell Viability.

The Journal of investigative dermatology - 1 Mar 2018

Sawant Mugdha, Schwarz Nicole, Windoffer Reinhard, Magin Thomas M, Krieger Jan, Mücke Norbert, Obara Boguslaw, Jankowski Vera, Jankowski Joachim, Wally Verena, Lettner Thomas, Leube Rudolf E

Abstract excerpt

A characteristic feature of the skin blistering disease epidermolysis bullosa simplex is keratin filament (KF) network collapse caused by aggregation of the basal epidermal keratin type II (KtyII) K5 and its type I partner keratin 14 (K14). Here, we examine the role of keratin phosphorylation in KF network rearrangement and cellular functions. We detect phosphorylation of the K5 head domain residue T150 in...

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Identifiers

PMID: 29080682
DOI: 10.1016/j.jid.2017.10.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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