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Article

Interaction of Tim23 with Tim50 Is essential for protein translocation by the mitochondrial TIM23 complex.

The Journal of biological chemistry - 20 Feb 2009

Gevorkyan-Airapetov Lada, Zohary Keren, Popov-Celeketic Dusan, Mapa Koyeli, Hell Kai, Neupert Walter, Azem Abdussalam, Mokranjac Dejana

Abstract excerpt

The TIM23 complex is the major translocase of the mitochondrial inner membrane responsible for the import of essentially all matrix proteins and a number of inner membrane proteins. Tim23 and Tim50, two essential proteins of the complex, expose conserved domains into the intermembrane space that interact with each other. Here, we describe in vitro reconstitution of this interaction using recombinantly expressed...

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Identifiers

PMID: 19017642
DOI: 10.1074/jbc.M807041200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Interaction of Tim23 with Tim50 Is essential for protein translocation by the mitochondrial TIM23 complex.PMID 19017642Read ↗

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