Article
Mutational landscape and genetic signatures of cell-free DNA in tumour-induced osteomalacia.
Journal of cellular and molecular medicine - 1 May 2020
Wu Nan, Zhang Zhen, Zhou Xi, Zhao Hengqiang, Ming Yue, Wu Xue, Zhang Xian, Yang Xin-Zhuang, Zhou Meng, Bao Hua, Chen Weisheng, Wu Yong, Liu Sen, Wang Huizi, Niu Yuchen, Li Yalun, Zheng Yu, Shao Yang, Gao Na, Yang Ying, Liu Ying, Li Wenli, Liu Jia, Zhang Na, Yang Xu, Xu Yuan, Li Mei, Sun Yingli, Su Jianzhong, Zhang Jianguo, Xia Weibo, Qiu Guixing, Liu Yong, Liu Jiaqi, Wu Zhihong
Abstract excerpt
Tumour-induced osteomalacia (TIO) is a very rare paraneoplastic syndrome with bone pain, fractures and muscle weakness, which is mostly caused by phosphaturic mesenchymal tumours (PMTs). Cell-free DNA (cfDNA) has been regarded as a non-invasive liquid biopsy for many malignant tumours. However, it has not been studied in benign tumours, which prompted us to adopt the targeted next-generation sequencing approach...
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