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Article

The influence of ABCG2 polymorphism on erlotinib efflux in the K562 cell line.

Pharmacology research & perspectives - 1 Apr 2020

Svedberg Anna, Jacobs Lianne, Vikingsson Svante, Gréen Henrik

Abstract excerpt

Single nucleotide polymorphisms (SNPs) in the gene for multidrug resistance protein ABCG2, an erlotinib transporter, is a possible contributor to the interindividual variation observed in erlotinib pharmacokinetics and toxicity. Therefore, the aim was to study erlotinib efflux by ABCG2 wild-type (wt) and ABCG2 polymorphic variants in the K562 cell line. The chronic myeloid leukemia K562 cell line, neither...

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Share to Antineoplastic Agents
Share to ATP Binding Cassette Transporter, Subfamily G, Member 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Erlotinib Hydrochloride

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Source

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Identifiers

PMID: 32266784
DOI: 10.1002/prp2.581
PMCID: PMC7138917

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