Evaluation of a Hybrid Capture-Based Pan-Cancer Panel for Analysis of Treatment Stratifying Oncogenic Aberrations and Processes.

doi:10.1016/j.jmoldx.2020.02.009

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Article

Evaluation of a Hybrid Capture-Based Pan-Cancer Panel for Analysis of Treatment Stratifying Oncogenic Aberrations and Processes.

The Journal of molecular diagnostics : JMD - 1 Jun 2020

Kroeze Leonie I, de Voer Richarda M, Kamping Eveline J, von Rhein Daniel, Jansen Erik A M, Hermsen Mandy J W, Barberis Massimo C P, Botling Johan, Garrido-Martin Eva M, Haller Florian, Lacroix Ludovic, Maes Brigitte, Merkelbach-Bruse Sabine, Pestinger Valerie, Pfarr Nicole, Stenzinger Albrecht, van den Heuvel Michel M, Grünberg Katrien, Ligtenberg Marjolijn J L

Abstract excerpt

Stratification of patients for targeted and immune-based therapies requires extensive genomic profiling that enables sensitive detection of clinically relevant variants and interrogation of biomarkers, such as tumor mutational burden (TMB) and microsatellite instability (MSI). Detection of single and multiple nucleotide variants, copy number variants, MSI, and TMB was evaluated using a commercially available...

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PMID: 32205293
DOI: 10.1016/j.jmoldx.2020.02.009

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