Association between circulating vitamin D, the Taq1 vitamin D receptor gene polymorphism and colorectal cancer risk among Jordanians.

doi:10.7314/apjcp.2014.15.17.7337

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Article

Association between circulating vitamin D, the Taq1 vitamin D receptor gene polymorphism and colorectal cancer risk among Jordanians.

Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2014

Atoum Manar Fayiz, Tchoporyan Melya Nizar

Abstract excerpt

BACKGROUND: The physiological role of vitamin D extends beyond bone health and calcium-phosphate homeostasis to effects on cancer risk, mainly for colorectal cancer. Vitamin D may have an anticancer effect in colorectal cancer mediated by binding of the active form 1,25(OH)2D to the vitamin D receptor (VDR). The Taq1 VDR gene polymorphism, a C-to-T base substitution (rs731236) in exon 9 may influence its...

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PMID: 25227839
DOI: 10.7314/apjcp.2014.15.17.7337

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