The -4817 G>A (rs2238136) variant of the vitamin D receptor gene: a probable risk factor for colorectal cancer.

doi:10.1007/s11033-011-1325-x

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The -4817 G>A (rs2238136) variant of the vitamin D receptor gene: a probable risk factor for colorectal cancer.

Molecular biology reports - 1 May 2012

Mahmoudi Touraj, Arkani Maral, Karimi Khatoon, Safaei Akram, Rostami Fatemeh, Arbabi Elham, Pourhoseingholi Mohamad Amin, Mohebbi Seyed Reza, Nikzamir Abdolrahim, Romani Sara, Almasi Shohreh, Abbaszadeh Maryam, Vafaei Mohammad, Zali Mohammad Reza

Abstract excerpt

Vitamin D appears to have anti-tumor activities in the large bowel. Our aim was to investigate whether -4817 G>A (rs2238136) polymorphism located at 5'-untranslated region (5'-UTR) of the human vitamin D receptor (VDR) gene was associated with colorectal cancer (CRC) risk. We conducted a case-control study and VDR genotypes, determined by Bpu10I restriction endonuclease digestion of PCR-amplified DNA, were...

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PMID: 22167329
DOI: 10.1007/s11033-011-1325-x

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