Article
The cis-encoded antisense RNA IsrA from Salmonella Typhimurium represses the expression of STM0294.1n (iasE), an SOS-induced gene coding for an endoribonuclease activity.
Biochemical and biophysical research communications - 4 Jun 2020
Acuña Lillian G, Barros M José, Nuñez Paula, Peñaloza Diego, Montt Fernanda, Pedraza Diego, Crossley Katherine, Gil Fernando, Fuentes Juan A, Calderón Iván L
Abstract excerpt
Toxin-antitoxin systems are known to be involved in many bacterial functions that can lead to growth arrest and cell death in response to stress. Typically, toxin and antitoxin genes of type I systems are located in opposite strands, where the antitoxin is a small antisense RNA (sRNA). In the present work we show that the sRNA IsrA from Salmonella Typhimurium down-regulates the expression of its overlapping gene...
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