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Article

Minimal modification in the factor VIII B-domain sequence ameliorates the murine hemophilia A phenotype.

Blood - 23 May 2013

Siner Joshua I, Iacobelli Nicholas P, Sabatino Denise E, Ivanciu Lacramiora, Zhou Shangzhen, Poncz Mortimer, Camire Rodney M, Arruda Valder R

Abstract excerpt

Recombinant canine B-domain deleted (BDD) factor VIII (FVIII) is predominantly expressed as a single-chain protein and exhibits greater stability after activation compared with human FVIII-BDD. We generated a novel BDD-FVIII variant (FVIII-RH) with an amino acid change at the furin cleavage site within the B domain (position R1645H) that mimics the canine sequence (HHQR vs human RHQR). Compared with human...

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Identifiers

PMID: 23372167
DOI: 10.1182/blood-2012-10-464164
PMCID: PMC3663432

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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