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Article

Codon optimization of human factor VIII cDNAs leads to high-level expression.

Blood - 20 Jan 2011

Ward Natalie J, Buckley Suzanne M K, Waddington Simon N, Vandendriessche Thierry, Chuah Marinee K L, Nathwani Amit C, McIntosh Jenny, Tuddenham Edward G D, Kinnon Christine, Thrasher Adrian J, McVey John H

Abstract excerpt

Gene therapy for hemophilia A would be facilitated by development of smaller expression cassettes encoding factor VIII (FVIII), which demonstrate improved biosynthesis and/or enhanced biologic properties. B domain deleted (BDD) FVIII retains full procoagulant function and is expressed at higher levels than wild-type FVIII. However, a partial BDD FVIII, leaving an N-terminal 226 amino acid stretch (N6), increases...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21041718
DOI: 10.1182/blood-2010-05-282707

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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