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Article

Circumventing furin enhances factor VIII biological activity and ameliorates bleeding phenotypes in hemophilia models.

JCI insight - 6 Oct 2016

Siner Joshua I, Samelson-Jones Benjamin J, Crudele Julie M, French Robert A, Lee Benjamin J, Zhou Shanzhen, Merricks Elizabeth, Raymer Robin, Nichols Timothy C, Camire Rodney M, Arruda Valder R

Abstract excerpt

Processing by the proprotein convertase furin is believed to be critical for the biological activity of multiple proteins involved in hemostasis, including coagulation factor VIII (FVIII). This belief prompted the retention of the furin recognition motif (amino acids 1645-1648) in the design of B-domain-deleted FVIII (FVIII-BDD) products in current clinical use and in the drug development pipeline, as well as in...

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Identifiers

PMID: 27734034
DOI: 10.1172/jci.insight.89371
PMCID: PMC5053153

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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